The relationship of HLA-G 14-bp insertion/deletion genetic polymorphism to the risk of multiple sclerosis and its clinical phenotypes

Abstract Background Human leukocyte antigen (HLA)-G molecule has been suggested to have a potential immunomodulatory role in multiple sclerosis (MS). Genetic variant sites of HLA-G reported be associated with autoimmune diseases. Identifying the genetic risk factors MS may help preventive strategies and anticipating disease progression. The aim this work was investigate effect 14-base-pair insertion/deletion (14-bp INS/DEL) polymorphism on clinical characteristics observe patients’ group. study included 48 patients 50 cross-matched healthy controls, who were recruited from Sohag Assiut university hospitals. testing Ins/Del gene polymorphism) using polymerase chain reaction (PCR) performed for control groups. All had detailed assessment undergone measurement disability Expanded Disability Status Scale (EDSS). Results No statistically significant difference found between controls (HC) genotypic allelic frequencies 14-bp INS/DEL ( P =0.305). association genotypes or degree patients. most frequent presenting symptoms motor symptoms. Fatigue symptom along course disease. Conclusion Although it long known that represents an important susceptibility locus, study, no relation could detected genotype susceptibility. not linked single allele but depend combination different polymorphic sites. In lack attributed ethnic factor.